nterleukin-6 (IL-6) is an endogenous chemical which is active in inflammation, and in lymph cell maturation. Besides being an immune protein, it’s also a pyrogen, and is answerable for fever in autoimmune, infectious or non-infectious disease. it’s produced within the body, wherever there’s inflammation, either acute or chronic. This includes situations like trauma, burns, cancers and infection. It interacts with interleukin-6 receptor alpha, to induce transcription of inflammatory gene products.
Interleukin-6 is implicated during a host of chronic disease conditions related to inflammation. Interleukin-6 is additionally suspected to cause increased susceptibility to DM, and to the systemic sort of juvenile rheumatism.
Interleukin-6 is released by monocytes and macrophages in response to other inflammatory cytokines which include interleukin-11, and tumor necrosis factor (TNF)-beta. The IL-6 receptor is present on normal T-lymphocytes within the resting phase, normal activated B-cells, and cells within the myeloid and hepatic cell lines. it’s also found on B cells modified by the herpes.